The impact of cystic fibrosis and PSTI/SPINK1 gene mutations on susceptibility to chronic pancreatitis

Clin Lab Med. 2005 Mar;25(1):79-100. doi: 10.1016/j.cll.2004.12.007.

Abstract

This article reviews current concepts regarding the pathobiology of cystic fibrosis pancreatic disease. It summarizes recent studies on the relationship between CFTR mutations and pancreatitis, and it reviews several unresolved issues in the field.

Publication types

  • Review

MeSH terms

  • Carrier Proteins / genetics*
  • Carrier Proteins / metabolism
  • Chronic Disease
  • Cystic Fibrosis / epidemiology
  • Cystic Fibrosis / genetics*
  • Cystic Fibrosis / physiopathology
  • Cystic Fibrosis Transmembrane Conductance Regulator / genetics*
  • Cystic Fibrosis Transmembrane Conductance Regulator / metabolism
  • Genetic Predisposition to Disease
  • Humans
  • Pancreatitis / epidemiology
  • Pancreatitis / genetics*
  • Pancreatitis / physiopathology
  • Risk Factors
  • Trypsin Inhibitor, Kazal Pancreatic

Substances

  • CFTR protein, human
  • Carrier Proteins
  • SPINK1 protein, human
  • Cystic Fibrosis Transmembrane Conductance Regulator
  • Trypsin Inhibitor, Kazal Pancreatic