Abstract
DermaVir is a novel topical immunisation designed to target Langerhans cells (LC), the epidermal precursors of dendritic cells. LC serve as a vehicle to process and transfer antigens from the skin to T cell areas in the lymphoid organs. The HIV DNA delivered by DermaVir to LC expresses most viral regulatory and structural genes and induces T cell-mediated immune responses with broad specificity. In chronically infected macaques, DermaVir administered with antiretroviral drugs, suppressed viral load rebound after treatment interruption and improved survival. DermaVir is a promising antiretroviral treatment approach with a unique mechanism of action for combination with currently used drugs.
MeSH terms
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AIDS Vaccines / administration & dosage
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AIDS Vaccines / genetics
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AIDS Vaccines / isolation & purification*
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Administration, Topical
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Animals
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Antigen Presentation
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Biotechnology
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HIV Infections / immunology
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HIV Infections / therapy
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HIV-1 / genetics
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HIV-1 / immunology
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Humans
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Immunity, Cellular
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Langerhans Cells / immunology
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Macaca
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SAIDS Vaccines / administration & dosage
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SAIDS Vaccines / genetics
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SAIDS Vaccines / isolation & purification
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Simian Immunodeficiency Virus / genetics
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Simian Immunodeficiency Virus / immunology
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Vaccines, DNA / administration & dosage
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Vaccines, DNA / genetics
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Vaccines, DNA / isolation & purification
Substances
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AIDS Vaccines
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SAIDS Vaccines
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Vaccines, DNA