The immunoepidemiology of human hookworm infection

R J Quinnell; J Bethony; D I Pritchard

doi:10.1111/j.0141-9838.2004.00727.x

The immunoepidemiology of human hookworm infection

Parasite Immunol. 2004 Nov-Dec;26(11-12):443-54. doi: 10.1111/j.0141-9838.2004.00727.x.

Authors

R J Quinnell¹, J Bethony, D I Pritchard

Affiliation

¹ School of Biology, University of Leeds, Leeds LS2 9JT, UK. r.j.quinnell@leeds.ac.uk

PMID: 15771680
DOI: 10.1111/j.0141-9838.2004.00727.x

Abstract

Advances in hookworm immunoepidemiology are reviewed. Recent studies demonstrate a mixed Th1/Th2 response in human hookworm infection, with immunosuppression of specific and nonspecific IFN-gamma responses. There is increasing evidence for protective immunity in human hookworm infection, including anti-larval IL-5- and IgE-dependent mechanisms, and for immunological interactions between hookworm infection and other diseases.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Ancylostoma / immunology*
Ancylostoma / pathogenicity
Ancylostomiasis / epidemiology
Ancylostomiasis / immunology
Ancylostomiasis / parasitology
Animals
Hookworm Infections / epidemiology*
Hookworm Infections / immunology*
Hookworm Infections / parasitology
Humans
Necator americanus / immunology*
Necator americanus / pathogenicity
Necatoriasis / epidemiology
Necatoriasis / immunology
Necatoriasis / parasitology