Abstract
Tubulin-binding agents play a pivotal role in current cancer therapy and there are many efforts in pre-clinical and clinical development of known and novel cytotoxic agents ongoing. In this article a known class, epothilones, as well as a novel class, tubulysins, are presented.
MeSH terms
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology*
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Apoptosis / drug effects
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Emetine / analogs & derivatives*
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Emetine / chemical synthesis
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Emetine / chemistry
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Emetine / isolation & purification*
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Emetine / pharmacology*
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Indicators and Reagents
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Models, Molecular
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Molecular Conformation
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Myxococcales / chemistry*
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Tubulin / analogs & derivatives*
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Tubulin / chemical synthesis
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Tubulin / chemistry
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Tubulin / isolation & purification*
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Tubulin / pharmacology
Substances
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Antineoplastic Agents
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Indicators and Reagents
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Tubulin
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tubulosine
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Emetine