Myxobacterial epothilones and tubulysins as promising anticancer agents

Mol Divers. 2005;9(1-3):141-7. doi: 10.1007/s11030-005-1542-0.

Abstract

Tubulin-binding agents play a pivotal role in current cancer therapy and there are many efforts in pre-clinical and clinical development of known and novel cytotoxic agents ongoing. In this article a known class, epothilones, as well as a novel class, tubulysins, are presented.

MeSH terms

  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology*
  • Apoptosis / drug effects
  • Emetine / analogs & derivatives*
  • Emetine / chemical synthesis
  • Emetine / chemistry
  • Emetine / isolation & purification*
  • Emetine / pharmacology*
  • Indicators and Reagents
  • Models, Molecular
  • Molecular Conformation
  • Myxococcales / chemistry*
  • Tubulin / analogs & derivatives*
  • Tubulin / chemical synthesis
  • Tubulin / chemistry
  • Tubulin / isolation & purification*
  • Tubulin / pharmacology

Substances

  • Antineoplastic Agents
  • Indicators and Reagents
  • Tubulin
  • tubulosine
  • Emetine