Abstract
In our large observational cohort, use of tenofovir disoproxil fumarate (n=344) was associated with a greater decline in renal function than was use of alternative nucleoside analogues (n=314). Other associations included a lower CD4 cell count, decreased renal function at baseline, and diabetes. The declines were modest and did not lead to greater rates of discontinuation of therapy.
Publication types
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Clinical Trial
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenine / adverse effects
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Adenine / analogs & derivatives*
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Adenine / therapeutic use
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Adult
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Anti-HIV Agents / adverse effects*
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Anti-HIV Agents / therapeutic use
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CD4 Lymphocyte Count
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Cohort Studies
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Creatinine / blood
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Female
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HIV Infections / drug therapy*
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Humans
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Kidney Diseases / chemically induced*
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Longitudinal Studies
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Male
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Middle Aged
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Organophosphonates / adverse effects*
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Organophosphonates / therapeutic use
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Reverse Transcriptase Inhibitors / adverse effects*
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Reverse Transcriptase Inhibitors / therapeutic use
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Tenofovir
Substances
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Anti-HIV Agents
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Organophosphonates
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Reverse Transcriptase Inhibitors
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Tenofovir
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Creatinine
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Adenine