Abstract
Immune responses to certain heat-shock proteins (HSPs) develop in almost all inflammatory diseases; however, the significance of such responses is only now becoming clear. In experimental disease models, HSPs can prevent or arrest inflammatory damage, and in initial clinical trials in patients with chronic inflammatory disease, HSP-derived peptides have been shown to promote the production of anti-inflammatory cytokines, indicating that HSPs have immunoregulatory potential. In this Review, we discuss the unique characteristics of HSPs that endow them with these immunoregulatory qualities.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Arteriosclerosis / drug therapy
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Arteriosclerosis / immunology
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Arteriosclerosis / metabolism
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Arthritis / drug therapy
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Arthritis / immunology
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Arthritis / metabolism
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Chaperonin 60 / immunology
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Chaperonin 60 / metabolism*
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Chronic Disease
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Clinical Trials as Topic
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Diabetes Mellitus, Type 1 / drug therapy
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Diabetes Mellitus, Type 1 / immunology
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Diabetes Mellitus, Type 1 / metabolism
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HSP70 Heat-Shock Proteins / immunology
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HSP70 Heat-Shock Proteins / metabolism*
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Humans
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Inflammation / drug therapy
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Inflammation / immunology
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Inflammation / metabolism*
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T-Lymphocytes / immunology
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T-Lymphocytes / metabolism*
Substances
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Chaperonin 60
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HSP70 Heat-Shock Proteins