Characterization and management of paradoxical upgrading reactions in HIV-uninfected patients with lymph node tuberculosis

Clin Infect Dis. 2005 May 1;40(9):1368-71. doi: 10.1086/429317. Epub 2005 Mar 23.

Abstract

In a retrospective analysis, paradoxical deterioration of lymph node tuberculosis in human immunodeficiency virus-uninfected patients was common, occurring in 25 (23%) of 109 patients after treatment had been given for a median of 46 days (interquartile range, 21-139 days) and persisting for a median of 67.5 days (interquartile range, 34-111 days). We found no association between the use of steroids and the duration of reaction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adrenal Cortex Hormones / adverse effects
  • Adrenal Cortex Hormones / therapeutic use*
  • Adult
  • Aged
  • Aged, 80 and over
  • Antitubercular Agents / adverse effects
  • Antitubercular Agents / therapeutic use*
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Male
  • Middle Aged
  • Retrospective Studies
  • Tuberculosis, Lymph Node / drug therapy*

Substances

  • Adrenal Cortex Hormones
  • Antitubercular Agents