Clinical and electrophysiologic correlates of IVIg responsiveness in CIDP

Neurology. 2005 Apr 26;64(8):1471-5. doi: 10.1212/01.WNL.0000158680.89323.F8.

Abstract

To identify clinical and electrophysiologic features related to IV immunoglobulin (IVIg) responsiveness in chronic inflammatory demyelinating polyneuropathy (CIDP), the authors conducted a multicenter study on 312 patients with CIDP (199 responders and 113 nonresponders). Muscle atrophy and decreased compound muscle action potential were pronounced in nonresponders of IVIg. Male gender, longer disease duration, and slow progression of symptoms were also associated with IVIg unresponsiveness. Features suggesting axonal dysfunction in peripheral nerves indicated IVIg unresponsiveness in CIDP.

Publication types

  • Clinical Trial
  • Multicenter Study

MeSH terms

  • Adult
  • Age of Onset
  • Aged
  • Axons / drug effects
  • Axons / immunology
  • Axons / pathology
  • Disease Progression
  • Drug Resistance / immunology
  • Female
  • Humans
  • Immunoglobulins, Intravenous / pharmacology*
  • Immunoglobulins, Intravenous / therapeutic use*
  • Male
  • Middle Aged
  • Motor Neurons / drug effects
  • Motor Neurons / immunology
  • Motor Neurons / pathology
  • Muscular Atrophy / drug therapy
  • Muscular Atrophy / immunology
  • Muscular Atrophy / physiopathology
  • Neural Conduction / drug effects
  • Neural Conduction / immunology
  • Neurons, Afferent / drug effects
  • Neurons, Afferent / immunology
  • Neurons, Afferent / pathology
  • Peripheral Nerves / drug effects*
  • Peripheral Nerves / immunology
  • Peripheral Nerves / physiopathology*
  • Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / drug therapy*
  • Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / immunology
  • Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / physiopathology
  • Sex Factors
  • Treatment Outcome

Substances

  • Immunoglobulins, Intravenous