Reversal of fibrogenic events in liver by Emblica officinalis (fruit), an Indian natural drug

Biol Pharm Bull. 2005 Jul;28(7):1304-6. doi: 10.1248/bpb.28.1304.

Abstract

A hydroalcoholic (50%) extract of Emblica officinalis (fruit) (EO-50) reduced the severity of hepatic fibrosis induced by carbon tetrachloride (CCl4) and thioacetamide (TAA). Improved liver function was observed by measuring the levels of aspartate aminotransaminase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and bilirubin in serum. Hepatic parameters monitored were the levels of glutathione (GSH), lipid peroxidation (LPO) and hydroxyproline and the activities of catalase, glutathione peroxidase (GPx), Na+,K+-ATPase and cytochrome P450 (CYP 450 2E1) (aniline hydroxylation). The results suggested that EO-50 effectively reversed profibrogenic events possibly due to its promising antioxidative activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alanine Transaminase / blood
  • Alkaline Phosphatase / blood
  • Animals
  • Aspartate Aminotransferases / blood
  • Carbon Tetrachloride / toxicity
  • Catalase / metabolism
  • Cytochrome P-450 CYP2E1 / metabolism
  • Glutathione / metabolism
  • Glutathione Peroxidase / metabolism
  • Lipid Peroxidation
  • Liver / enzymology
  • Liver Cirrhosis / blood
  • Liver Cirrhosis / chemically induced
  • Liver Cirrhosis / drug therapy*
  • Liver Cirrhosis / enzymology
  • Male
  • Phyllanthus emblica / chemistry*
  • Plant Extracts / therapeutic use*
  • Rats
  • Rats, Wistar
  • Sodium-Potassium-Exchanging ATPase / metabolism
  • Thioacetamide / toxicity

Substances

  • Plant Extracts
  • Thioacetamide
  • Carbon Tetrachloride
  • Catalase
  • Glutathione Peroxidase
  • Cytochrome P-450 CYP2E1
  • Aspartate Aminotransferases
  • Alanine Transaminase
  • Alkaline Phosphatase
  • Sodium-Potassium-Exchanging ATPase
  • Glutathione