The histamine H4 receptor as a new therapeutic target for inflammation

Trends Pharmacol Sci. 2005 Sep;26(9):462-9. doi: 10.1016/j.tips.2005.07.002.

Abstract

Following the sequencing of the human genome, data-mining efforts have revealed the existence of a new histamine receptor that is expressed at high levels in mast cells and leukocytes. The histamine H(4) receptor has a distinct pharmacological profile and the first compounds that act selectively on the H(4) receptor have been developed. Initial experiments in vivo with H(4) receptor antagonists indicate a role for the H(4) receptor in inflammatory conditions.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Calcium / metabolism
  • Humans
  • Inflammation / etiology*
  • Molecular Sequence Data
  • Receptors, G-Protein-Coupled / agonists
  • Receptors, G-Protein-Coupled / antagonists & inhibitors
  • Receptors, G-Protein-Coupled / physiology*
  • Receptors, Histamine / physiology*
  • Receptors, Histamine H4
  • Signal Transduction

Substances

  • HRH4 protein, human
  • Receptors, G-Protein-Coupled
  • Receptors, Histamine
  • Receptors, Histamine H4
  • Calcium