Abstract
REST/NRSF was first identified as a transcriptional repressor of neuronal genes in non-neuronal cells. Recent studies have now revealed seemingly paradoxical roles for REST/NRSF in neurogenesis, neural plasticity, tumour suppression and cancer progression.
MeSH terms
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Alternative Splicing / genetics
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Cell Differentiation / genetics*
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Co-Repressor Proteins
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DNA-Binding Proteins / metabolism
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Gene Expression Regulation*
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Humans
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Models, Biological*
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Neoplasms / metabolism*
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Nerve Tissue Proteins / metabolism
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Neurons / cytology*
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Repressor Proteins / genetics
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Repressor Proteins / metabolism*
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Transcription Factors / genetics
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Transcription Factors / metabolism*
Substances
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Co-Repressor Proteins
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DNA-Binding Proteins
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Nerve Tissue Proteins
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RCOR1 protein, human
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RE1-silencing transcription factor
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Repressor Proteins
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Transcription Factors