Transcriptional regulation: cancer, neurons and the REST

Curr Biol. 2005 Sep 6;15(17):R665-8. doi: 10.1016/j.cub.2005.08.032.

Abstract

REST/NRSF was first identified as a transcriptional repressor of neuronal genes in non-neuronal cells. Recent studies have now revealed seemingly paradoxical roles for REST/NRSF in neurogenesis, neural plasticity, tumour suppression and cancer progression.

Publication types

  • Review

MeSH terms

  • Alternative Splicing / genetics
  • Cell Differentiation / genetics*
  • Co-Repressor Proteins
  • DNA-Binding Proteins / metabolism
  • Gene Expression Regulation*
  • Humans
  • Models, Biological*
  • Neoplasms / metabolism*
  • Nerve Tissue Proteins / metabolism
  • Neurons / cytology*
  • Repressor Proteins / genetics
  • Repressor Proteins / metabolism*
  • Transcription Factors / genetics
  • Transcription Factors / metabolism*

Substances

  • Co-Repressor Proteins
  • DNA-Binding Proteins
  • Nerve Tissue Proteins
  • RCOR1 protein, human
  • RE1-silencing transcription factor
  • Repressor Proteins
  • Transcription Factors