Irinotecan (CPT-11) combined with cisplatin for small cell carcinoma of the nasal cavity

Nobuhiro Hakuba; Masamitsu Hyodo; Takashi Yokoi; Hidemitsu Sato

doi:10.1016/j.anl.2005.07.006

Irinotecan (CPT-11) combined with cisplatin for small cell carcinoma of the nasal cavity

Auris Nasus Larynx. 2006 Mar;33(1):67-70. doi: 10.1016/j.anl.2005.07.006. Epub 2005 Sep 15.

Authors

Nobuhiro Hakuba¹, Masamitsu Hyodo, Takashi Yokoi, Hidemitsu Sato

Affiliation

¹ Department of Otolaryngology, Ehime University School of Medicine, Shigenobu-cho, Onsen-gun Ehime 791-0295, Japan. hakubax@m.ehime-u.ac.jp

PMID: 16168589
DOI: 10.1016/j.anl.2005.07.006

Abstract

We describe a case of small cell carcinoma arising in the nasal cavity using combined chemotherapy with irinotecan (CPT-11)/cisplatin followed by surgical salvage which successfully avoided a radical operation. In a follow-up no local recurrence was observed over 3 years after the operation. Ours is the first report of the use of combined irinotecan (CPT-11)/cisplatin chemotherapy in small cell carcinoma of the nasal cavity.

Publication types

Case Reports

MeSH terms

Aged
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Camptothecin / administration & dosage
Camptothecin / analogs & derivatives
Carcinoma, Small Cell / drug therapy*
Carcinoma, Small Cell / surgery
Cisplatin / administration & dosage
Female
Humans
Irinotecan
Nasal Cavity / pathology*
Nasal Cavity / surgery
Neoadjuvant Therapy
Nose Neoplasms / drug therapy*
Nose Neoplasms / surgery

Substances

Irinotecan
Cisplatin
Camptothecin