Abstract
The free radical scavenging and anti-cancer activites of Pinus morrisonicola Hay. were studied using different parts of the pine, namely, needle, bark and cone. Results showed that pine needle water extract has the highest scavenging superoxide anion activity and the lowest IC50 value in inhibiting superoxide anion formation; however, the bark water extract showed the best anti-lipid peroxidation activity. Additionally, needle water extract displayed the highest inhibition of leukemia cell line U937 growth. The results indicated that P. morrisonicola Hay. possesses potential chemopreventative and therapeutic properties.
MeSH terms
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Animals
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Antineoplastic Agents, Phytogenic / administration & dosage
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Antineoplastic Agents, Phytogenic / pharmacology
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Antineoplastic Agents, Phytogenic / therapeutic use
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Antioxidants / administration & dosage
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Antioxidants / pharmacology*
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Antioxidants / therapeutic use
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Free Radical Scavengers / administration & dosage
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Free Radical Scavengers / pharmacology
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Free Radical Scavengers / therapeutic use
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Humans
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Inhibitory Concentration 50
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Lipid Peroxidation / drug effects*
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Phytotherapy*
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Pinus*
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Plant Components, Aerial
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Plant Extracts / administration & dosage
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Plant Extracts / pharmacology*
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Plant Extracts / therapeutic use
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Rats
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Superoxides / metabolism
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U937 Cells / drug effects
Substances
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Antineoplastic Agents, Phytogenic
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Antioxidants
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Free Radical Scavengers
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Plant Extracts
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Superoxides