Abstract
The recent discovery of PTPN22 as a novel susceptibility gene in human type 1 diabetes and continued progress in defining genes in animal models of the disease mark a fruitful period in the field of type 1 diabetes genetics. In addition, the similarities of the genetic and functional aspects across species have been substantiated. Future genome-wide association studies will reveal more loci, each providing a piece to the genetic puzzle of autoimmune disease.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antigens, CD
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Antigens, Differentiation / genetics
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CTLA-4 Antigen
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Diabetes Mellitus, Type 1 / genetics*
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Genetic Linkage
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Genetic Predisposition to Disease*
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Humans
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Insulin / genetics
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Interleukin-2 Receptor alpha Subunit
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Major Histocompatibility Complex
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Mice
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Mice, Inbred NOD
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Protein Tyrosine Phosphatase, Non-Receptor Type 1
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Protein Tyrosine Phosphatase, Non-Receptor Type 22
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Protein Tyrosine Phosphatases / genetics
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Receptors, Interleukin / genetics
Substances
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Antigens, CD
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Antigens, Differentiation
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CTLA-4 Antigen
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CTLA4 protein, human
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Ctla4 protein, mouse
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IL2RA protein, human
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Il2ra protein, mouse
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Insulin
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Interleukin-2 Receptor alpha Subunit
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Receptors, Interleukin
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PTPN22 protein, human
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Protein Tyrosine Phosphatase, Non-Receptor Type 1
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Protein Tyrosine Phosphatase, Non-Receptor Type 22
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Protein Tyrosine Phosphatases
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Ptpn22 protein, mouse