Type 2 diabetes mellitus in youth: the complete picture to date

Pediatr Clin North Am. 2005 Dec;52(6):1579-609. doi: 10.1016/j.pcl.2005.07.009.

Abstract

Type 2 diabetes mellitus is a heterogeneous condition in which the clinical manifestation of hyperglycemia is a reflection of the impaired balance between insulin sensitivity and insulin secretion. Clinical experience and research in youth type 2 diabetes mellitus are in an early stage because of the relative novelty of the condition in pediatrics. This article discusses the amassed information in type 2 diabetes mellitus of youth to date with respect to the epidemiology, pathophysiology, risk factors, clinical presentation, screening, and management strategies.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Autoantibodies / blood
  • Child
  • Diabetes Complications / metabolism
  • Diabetes Complications / therapy
  • Diabetes Mellitus, Type 2 / diagnosis
  • Diabetes Mellitus, Type 2 / immunology
  • Diabetes Mellitus, Type 2 / therapy*
  • Diet
  • Dyslipidemias / drug therapy
  • Dyslipidemias / etiology
  • Humans
  • Hyperglycemia / drug therapy
  • Hyperglycemia / etiology
  • Hypertension / drug therapy
  • Hypertension / etiology
  • Hypoglycemic Agents / therapeutic use
  • Insulin Resistance
  • Insulin-Secreting Cells / pathology
  • Life Style
  • Metformin / therapeutic use
  • Risk Factors

Substances

  • Autoantibodies
  • Hypoglycemic Agents
  • Metformin