Role of RANKL in physiological and pathological bone resorption and therapeutics targeting the RANKL-RANK signaling system

Immunol Rev. 2005 Dec:208:30-49. doi: 10.1111/j.0105-2896.2005.00327.x.

Abstract

Osteoclasts are primary cells for physiological and pathological bone resorption, and receptor activator of nuclear factor-kappaB ligand (RANKL) is critically involved in the differentiation, activation, and survival of these cells. Recently, therapeutics for pathological bone destruction targeting RANKL pathways has attracted a great deal of attention. Herein, we review the recent advances in the research on osteoclast biology and discuss the advantages and disadvantages of anti-RANKL therapies.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis
  • Arthritis, Rheumatoid / etiology
  • Bone Resorption / etiology*
  • Bone Resorption / therapy
  • Carrier Proteins / antagonists & inhibitors
  • Carrier Proteins / physiology*
  • Cell Differentiation
  • Glycoproteins / antagonists & inhibitors*
  • Glycoproteins / physiology
  • Humans
  • Membrane Glycoproteins / antagonists & inhibitors
  • Membrane Glycoproteins / physiology*
  • NF-kappa B / physiology
  • Osteoclasts / cytology
  • Osteoclasts / physiology
  • Osteoporosis / etiology
  • Osteoprotegerin
  • Periodontal Diseases / etiology
  • Proto-Oncogene Proteins c-bcl-2 / physiology
  • RANK Ligand
  • Receptor Activator of Nuclear Factor-kappa B
  • Receptors, Cytoplasmic and Nuclear / antagonists & inhibitors*
  • Receptors, Cytoplasmic and Nuclear / physiology
  • Receptors, Tumor Necrosis Factor / antagonists & inhibitors*
  • Receptors, Tumor Necrosis Factor / physiology
  • Signal Transduction*
  • TNF Receptor-Associated Factor 6 / physiology

Substances

  • Carrier Proteins
  • Glycoproteins
  • Membrane Glycoproteins
  • NF-kappa B
  • Osteoprotegerin
  • Proto-Oncogene Proteins c-bcl-2
  • RANK Ligand
  • Receptor Activator of Nuclear Factor-kappa B
  • Receptors, Cytoplasmic and Nuclear
  • Receptors, Tumor Necrosis Factor
  • TNF Receptor-Associated Factor 6
  • TNFRSF11A protein, human
  • TNFRSF11B protein, human
  • TNFSF11 protein, human