In vivo microdialysis for PK and PD studies of anticancer drugs

AAPS J. 2005 Oct 24;7(3):E659-67. doi: 10.1208/aapsj070366.

Abstract

In vivo microdialysis technique has become one of the major tools to sample endogenous and exogenous substances in extracellular spaces. As a well-validated sampling technique, microdialysis has been frequently employed for quantifying drug disposition at the desired target in both preclinical and clinical settings. This review addresses general methodological considerations critical to performing microdialysis in tumors, highlights selected preclinical and clinical studies that characterized drug disposition in tumors by the use of microdialysis, and illustrates the potential application of microdialysis in the assessment of tumor response to cancer treatment.

Publication types

  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacokinetics*
  • Antineoplastic Agents / pharmacology
  • Humans
  • Microdialysis / methods*
  • Neoplasms / drug therapy
  • Neoplasms / metabolism
  • Pharmacokinetics

Substances

  • Antineoplastic Agents