Rapid and efficient synthesis of poly-substituted quinolines assisted by p-toluene sulphonic acid under solvent-free conditions: comparative study of microwave irradiation versus conventional heating

Cheng-Sheng Jia; Ze Zhang; Shu-Jiang Tu; Guan-Wu Wang

doi:10.1039/b513721g

Rapid and efficient synthesis of poly-substituted quinolines assisted by p-toluene sulphonic acid under solvent-free conditions: comparative study of microwave irradiation versus conventional heating

Org Biomol Chem. 2006 Jan 7;4(1):104-10. doi: 10.1039/b513721g. Epub 2005 Nov 18.

Authors

Cheng-Sheng Jia¹, Ze Zhang, Shu-Jiang Tu, Guan-Wu Wang

Affiliation

¹ Hefei National Laboratory for Physical Sciences at Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, PR China.

PMID: 16358003
DOI: 10.1039/b513721g

Abstract

A rapid and efficient method for the preparation of various poly-substituted quinolines has been developed through the Friedländer condensation of 2-aminoarylketone or 2-aminoarylaldehyde with carbonyl compounds in the presence of p-toluene sulphonic acid, which was achieved by both microwave irradiation and conventional heating under solvent-free conditions.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Aldehydes / chemistry
Arylsulfonates / chemistry
Benzenesulfonates / chemistry*
Hot Temperature*
Ketones / chemistry
Microwaves*
Quinolines / chemical synthesis*
Toluene / chemistry

Substances

Aldehydes
Arylsulfonates
Benzenesulfonates
Ketones
Quinolines
Toluene
4-toluenesulfonic acid