There are no long-term clinical studies concerning the treatment outcome of CAD/CAM generated porcelain laminate veneers. The objective of this study was to conduct a longitudinal evaluation of CAD/CAM fabricated porcelain laminate veneers. A single practitioner placed 715 CAD/CAM generated porcelain laminate veneers produced chairside with the Cerec system on 307 patients between December 1989 and December 1997. 260 patients with 617 veneers were available for recall examination. Forty-seven patients with 98 veneers (13.7%) were unable to be located or return for recall examination. Fourteen restorations had been lost. The Kaplan-Meier survival rate was 94% after up to 9 years (95% confidence interval: 90.7 to 97.8%). Of the surviving restorations, 98% were classified as clinically acceptable after 9 years. 97.3% of the teeth examined tested vital, 96.2% of the veneers were asymptomatic since their production, 98.8% of the veneers were considered successful by the patient. CAD/CAM veneers fabricated with the Cerec System achieved comparable long-term clinical results to those reported for laboratory processed porcelain laminate veneers. The high survival rate and favorable clinical results would support the use of CAD/CAM porcelain laminate veneers in clinical situations similar to those for laboratory processed porcelain veneers. CAD/CAM generated porcelain laminate veneers may provide equally good clinical results and longevity as conventional laboratory-processed porcelain laminate veneers.