Getting a grip on licensing: mechanism of stable Mcm2-7 loading onto replication origins

Mol Cell. 2006 Jan 20;21(2):143-4. doi: 10.1016/j.molcel.2006.01.003.

Abstract

A recent Molecular Cell paper by Randell et al. (2006) sheds light on the role of ATP hydrolysis by Cdc6 in promoting the stable loading of the Mcm2-7 complex onto origins of DNA replication.

Publication types

  • Review
  • Comment

MeSH terms

  • Adenosine Triphosphate
  • Cell Cycle Proteins / metabolism*
  • Chromosomal Proteins, Non-Histone
  • DNA Replication
  • DNA-Binding Proteins / metabolism*
  • Fungal Proteins / metabolism*
  • Minichromosome Maintenance Complex Component 7
  • Models, Biological
  • Nuclear Proteins / metabolism*
  • Origin Recognition Complex / metabolism
  • Saccharomyces cerevisiae / metabolism
  • Saccharomyces cerevisiae Proteins / metabolism*

Substances

  • CDC6 protein, S cerevisiae
  • Cell Cycle Proteins
  • Chromosomal Proteins, Non-Histone
  • DNA-Binding Proteins
  • Fungal Proteins
  • Nuclear Proteins
  • Origin Recognition Complex
  • Saccharomyces cerevisiae Proteins
  • Adenosine Triphosphate
  • MCM2 protein, S cerevisiae
  • MCM7 protein, S cerevisiae
  • Minichromosome Maintenance Complex Component 7