Intermolecular cooperativity: a clue to why mice have IgG3?

Immunol Today. 1992 May;13(5):164-8. doi: 10.1016/0167-5699(92)90120-V.

Abstract

Mouse IgG3 subclass antibodies predominate in humoral responses to bacterial polysaccharide antigens. The reasons for this isotype restriction are not fully understood. Here, Neil Greenspan and Laurence Cooper propose that intermolecular cooperativity, a novel mechanism of antibody binding, may help to explain the preferential expression of IgG3 antibodies in these responses.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Antibodies, Bacterial / immunology*
  • Antibodies, Bacterial / metabolism
  • Antibodies, Monoclonal / immunology
  • Antibodies, Monoclonal / metabolism
  • Antibody Affinity*
  • Antigens, Bacterial / immunology*
  • Antigens, Bacterial / metabolism
  • Immunoglobulin Fc Fragments / metabolism
  • Immunoglobulin G / immunology*
  • Immunoglobulin G / metabolism
  • Mice / immunology*
  • Models, Biological*
  • Molecular Structure
  • Polysaccharides, Bacterial / immunology*
  • Polysaccharides, Bacterial / metabolism
  • Protein Binding
  • Protein Conformation
  • Structure-Activity Relationship

Substances

  • Antibodies, Bacterial
  • Antibodies, Monoclonal
  • Antigens, Bacterial
  • Immunoglobulin Fc Fragments
  • Immunoglobulin G
  • Polysaccharides, Bacterial