Isoflavonoids with antiestrogenic activity from Millettia pachycarpa

J Nat Prod. 2006 Jan;69(1):138-41. doi: 10.1021/np050341w.

Abstract

Three new isoflavonoids, named millewanins G (1) and H (2) and furowanin B (3), were isolated from the leaves of Millettia pachycarpa. Their structures were elucidated on the basis of spectroscopic analyses. The antiestrogenic activity in the yeast two-hybrid assay of these isoflavonoids was examined and shown to be comparable with that of 4-hydroxytamoxifen.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Estrogen Receptor Modulators* / chemistry
  • Estrogen Receptor Modulators* / isolation & purification
  • Estrogen Receptor Modulators* / pharmacology
  • Isoflavones* / chemistry
  • Isoflavones* / isolation & purification
  • Isoflavones* / pharmacology
  • Japan
  • Millettia / chemistry*
  • Molecular Structure
  • Plants, Medicinal / chemistry*
  • Yeasts / drug effects
  • beta-Galactosidase / antagonists & inhibitors

Substances

  • Estrogen Receptor Modulators
  • Isoflavones
  • furowanin B
  • millewanin G
  • millewanin H
  • beta-Galactosidase