Abstract
Some protease inhibitors use uncommon mechanisms to restrain the activity of their target enzymes. A recent paper in Chemistry and Biology (Lu et al., 2006) demonstrates a curious mechanism of inhibition of a caspase, relying on principles of native peptide ligation.
MeSH terms
-
Apoptosis
-
Caspase Inhibitors*
-
Inteins / physiology
-
Models, Biological
-
Protease Inhibitors / chemistry
-
Protease Inhibitors / pharmacology*
-
Viral Proteins / physiology
Substances
-
Caspase Inhibitors
-
Protease Inhibitors
-
Viral Proteins
-
p35 protein, Baculovirus