PlyPH, a bacteriolytic enzyme with a broad pH range of activity and lytic action against Bacillus anthracis

J Bacteriol. 2006 Apr;188(7):2711-4. doi: 10.1128/JB.188.7.2711-2714.2006.

Abstract

We have cloned a lytic enzyme, PlyPH, with a specific lytic effect on Bacillus anthracis strains. PlyPH remains active between pH 4 and 10.5, and a single dose rescued a significant percentage of mice infected intraperitoneally with an attenuated B. anthracis strain. We propose PlyPH as a novel therapeutic agent.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Anthrax
  • Bacillus anthracis / classification
  • Bacillus anthracis / metabolism*
  • Bacillus anthracis / physiology
  • Bacteriolysis*
  • Bacteriophages / enzymology*
  • Hydrogen-Ion Concentration
  • Mice
  • Substrate Specificity
  • Viral Proteins / chemistry
  • Viral Proteins / metabolism*

Substances

  • Viral Proteins