Abstract
Dentilisin is a major surface protease and virulence factor of the bacterium Treponema denticola. In this study, we found that T. denticola reduced inflammatory cytokines, including interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor alpha, in peripheral blood mononuclear cells through degradation by dentilisin.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Bacterial Proteins
-
Chymotrypsin / genetics
-
Chymotrypsin / physiology*
-
Electrophoresis, Polyacrylamide Gel
-
Humans
-
Immunoblotting
-
Interleukin-1 / genetics
-
Interleukin-1 / metabolism*
-
Interleukin-6 / genetics
-
Interleukin-6 / metabolism*
-
Mutation
-
Peptide Hydrolases
-
RNA, Messenger / metabolism
-
Recombinant Proteins / genetics
-
Recombinant Proteins / metabolism
-
Reverse Transcriptase Polymerase Chain Reaction
-
Treponema denticola / enzymology*
-
Treponema denticola / genetics
-
Treponema denticola / pathogenicity
-
Tumor Necrosis Factor-alpha / genetics
-
Tumor Necrosis Factor-alpha / metabolism*
Substances
-
Bacterial Proteins
-
Interleukin-1
-
Interleukin-6
-
RNA, Messenger
-
Recombinant Proteins
-
Tumor Necrosis Factor-alpha
-
Peptide Hydrolases
-
dentilisin
-
Chymotrypsin