The Treponema denticola surface protease dentilisin degrades interleukin-1 beta (IL-1 beta), IL-6, and tumor necrosis factor alpha

Infect Immun. 2006 Apr;74(4):2462-7. doi: 10.1128/IAI.74.4.2462-2467.2006.

Abstract

Dentilisin is a major surface protease and virulence factor of the bacterium Treponema denticola. In this study, we found that T. denticola reduced inflammatory cytokines, including interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor alpha, in peripheral blood mononuclear cells through degradation by dentilisin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacterial Proteins
  • Chymotrypsin / genetics
  • Chymotrypsin / physiology*
  • Electrophoresis, Polyacrylamide Gel
  • Humans
  • Immunoblotting
  • Interleukin-1 / genetics
  • Interleukin-1 / metabolism*
  • Interleukin-6 / genetics
  • Interleukin-6 / metabolism*
  • Mutation
  • Peptide Hydrolases
  • RNA, Messenger / metabolism
  • Recombinant Proteins / genetics
  • Recombinant Proteins / metabolism
  • Reverse Transcriptase Polymerase Chain Reaction
  • Treponema denticola / enzymology*
  • Treponema denticola / genetics
  • Treponema denticola / pathogenicity
  • Tumor Necrosis Factor-alpha / genetics
  • Tumor Necrosis Factor-alpha / metabolism*

Substances

  • Bacterial Proteins
  • Interleukin-1
  • Interleukin-6
  • RNA, Messenger
  • Recombinant Proteins
  • Tumor Necrosis Factor-alpha
  • Peptide Hydrolases
  • dentilisin
  • Chymotrypsin