Synthesis of the 3-aza-[7]-paracyclophane core of haouamine A and B

Org Lett. 2006 Apr 27;8(9):1901-4. doi: 10.1021/ol060455e.

Abstract

[reaction: see text] The synthesis of the highly strained 3-aza-[7]-paracyclophane core of haouamines A and B is based on a macrocyclization-aromatization protocol, allowing for a stepwise increase in ring strain and establishing the oxygenation pattern of the natural products.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aza Compounds / chemical synthesis*
  • Aza Compounds / chemistry
  • Crystallography, X-Ray
  • Heterocyclic Compounds, 4 or More Rings / chemical synthesis*
  • Heterocyclic Compounds, 4 or More Rings / chemistry
  • Molecular Conformation
  • Molecular Structure

Substances

  • Aza Compounds
  • Heterocyclic Compounds, 4 or More Rings
  • haouamine A
  • haouamine B