Keeping time without a clock

Ben Collins; Justin Blau

doi:10.1016/j.neuron.2006.04.022

Keeping time without a clock

Neuron. 2006 May 4;50(3):348-50. doi: 10.1016/j.neuron.2006.04.022.

Authors

Ben Collins¹, Justin Blau

Affiliation

¹ Biology Department, New York University, 100 Washington Square East, New York, New York 10003, USA.

PMID: 16675389
DOI: 10.1016/j.neuron.2006.04.022

Abstract

The accepted dogma in circadian biology is that the transcription factor CLOCK lies at the heart of the molecular clock that drives behavioral and molecular rhythms. In this issue of Neuron, the generation of CLOCK-deficient mice with only subtle clock defects by DeBruyne et al. shakes up this view of the mammalian clock.

Publication types

Comment
Review

MeSH terms

Animals
Biological Clocks / genetics*
CLOCK Proteins
Circadian Rhythm / genetics*
Gene Expression Regulation / physiology
Histone Acetyltransferases / metabolism
Humans
Mice
Mice, Knockout
Mutation / genetics*
Regulatory Elements, Transcriptional / physiology
Suprachiasmatic Nucleus / metabolism
Suprachiasmatic Nucleus / physiopathology
Trans-Activators / genetics*

Substances

Trans-Activators
CLOCK Proteins
CLOCK protein, human
Clock protein, mouse
Histone Acetyltransferases