Abstract
A series of 2-pyridinylpiperazines derived from beta-Ala-(2,4-Cl)Phe dipeptide was synthesized for the study of their SARs and possible interactions with the MC4 receptor. Compounds such as 11k (Ki=6.5 nM) possessed high potency.
MeSH terms
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Dipeptides / chemistry
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Drug Design
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Humans
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Piperazines / chemical synthesis*
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Piperazines / pharmacology*
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Pyridines / chemical synthesis*
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Pyridines / pharmacology*
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Receptor, Melanocortin, Type 4 / antagonists & inhibitors*
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Structure-Activity Relationship
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beta-Alanine / chemistry
Substances
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Dipeptides
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Piperazines
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Pyridines
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Receptor, Melanocortin, Type 4
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beta-Alanine