Subcutaneous fat tissue for diagnosis and studies of systemic amyloidosis

Per Westermark; Eva Davey; Karolina Lindbom; Stina Enqvist

doi:10.1016/j.acthis.2006.03.011

Subcutaneous fat tissue for diagnosis and studies of systemic amyloidosis

Acta Histochem. 2006;108(3):209-13. doi: 10.1016/j.acthis.2006.03.011. Epub 2006 May 22.

Authors

Per Westermark¹, Eva Davey, Karolina Lindbom, Stina Enqvist

Affiliation

¹ Rudbeck Laboratory, Department of Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden. Per.Westermark@genpat.uu.se

PMID: 16714055
DOI: 10.1016/j.acthis.2006.03.011

Abstract

The systemic amyloidoses comprise a biochemically heterogeneous group of potentially lethal disorders. An early and precise diagnosis is crucial for the treatment and prognosis. Subcutaneous fat biopsy is a simple and safe method to obtain a diagnosis of systemic amyloidosis and the material can be used for exact determination of amyloid type. A method is described for immunochemical typing of the amyloid based on Western blot analysis combined with specific amyloid fibril protein antibodies.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adipose Tissue / chemistry
Adipose Tissue / metabolism
Adipose Tissue / pathology*
Amyloid / analysis
Amyloid / classification
Amyloid / metabolism*
Amyloidosis / classification
Amyloidosis / diagnosis*
Amyloidosis / metabolism
Biopsy
Blotting, Western
Coloring Agents
Congo Red
Humans
Immunochemistry / methods
Subcutaneous Tissue / chemistry
Subcutaneous Tissue / metabolism
Subcutaneous Tissue / pathology*

Substances

Amyloid
Coloring Agents
Congo Red