Inhibition of rabies virus infection in cultured rat cortical neurons by an N-methyl-D-aspartate noncompetitive antagonist, MK-801

H Tsiang; P E Ceccaldi; A Ermine; B Lockhart; S Guillemer

doi:10.1128/AAC.35.3.572

Inhibition of rabies virus infection in cultured rat cortical neurons by an N-methyl-D-aspartate noncompetitive antagonist, MK-801

Antimicrob Agents Chemother. 1991 Mar;35(3):572-4. doi: 10.1128/AAC.35.3.572.

Authors

H Tsiang¹, P E Ceccaldi, A Ermine, B Lockhart, S Guillemer

Affiliation

¹ Rabies Unit, Pasteur Institute, Paris, France.

Abstract

A noncompetitive N-methyl-D-aspartate (NMDA) antagonist, MK-801 (0.5 to 2.0 mM), inhibits rabies virus infection in rat primary cortical neurons, whereas the competitive NMDA antagonist AP5 has no effect. The results suggest that MK-801-mediated inhibition of rabies virus replication, although selective, is not operating through the high-affinity binding site mechanism.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

2-Amino-5-phosphonovalerate / pharmacology
Animals
Cells, Cultured
Dizocilpine Maleate / pharmacology*
N-Methylaspartate / antagonists & inhibitors*
Neurons / drug effects*
Rabies / drug therapy
Rabies virus / drug effects*
Rats
Virus Replication / drug effects

Substances

N-Methylaspartate
Dizocilpine Maleate
2-Amino-5-phosphonovalerate