Abstract
A Japanese family consisting of a mother and her two daughters, all experienced NMS on therapeutic or subtherapeutic doses of neuroleptics. The mother and the elder daughter had past histories of severe neuroleptic-induced extrapyramidal symptoms. The predisposition to this syndrome may be genetically transmitted. We suggest that neuroleptic treatment should be introduced with extreme caution to a patient with a family history of NMS.
MeSH terms
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Adult
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Antipsychotic Agents / administration & dosage
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Antipsychotic Agents / adverse effects*
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Female
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Humans
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Neuroleptic Malignant Syndrome / diagnosis
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Neuroleptic Malignant Syndrome / genetics*
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Neurologic Examination
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Recurrence
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Risk Factors
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Schizophrenia / diagnosis
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Schizophrenia / drug therapy
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Schizophrenia / genetics*
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Schizophrenia, Catatonic / drug therapy
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Schizophrenia, Catatonic / genetics
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Schizophrenia, Catatonic / psychology
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Schizophrenic Psychology*