Abstract
The alpha-adrenergic activity of a dopamine receptor agonist, 2-di-n-propylamino-4,7-dimethoxyindane (RDS-127), has been studied on isolated rabbit and rat aortic strips. In both tissues, RDS-127 produced concentration-dependent contractions and its potency was not significantly different from that of phenylephrine. RDS-127-induced contractions were antagonized competitively by both prazosin and phentolamine in rabbit aortic strips, but the antagonists were noncompetitive in rat aortic strips.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adrenergic alpha-Agonists / pharmacology*
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Adrenergic alpha-Antagonists / pharmacology
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Animals
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Aorta, Thoracic / drug effects
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Dopamine Agents / pharmacology*
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Female
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In Vitro Techniques
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Indans / antagonists & inhibitors
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Indans / pharmacology*
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Male
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Muscle Contraction / drug effects
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Muscle, Smooth, Vascular / drug effects*
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Phentolamine / pharmacology
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Phenylephrine / antagonists & inhibitors
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Phenylephrine / pharmacology
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Prazosin / pharmacology
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Rabbits
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Rats
Substances
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Adrenergic alpha-Agonists
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Adrenergic alpha-Antagonists
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Dopamine Agents
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Indans
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Phenylephrine
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2-N,N-di-n-propylamino-4,7-dimethoxyindan
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Prazosin
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Phentolamine