Evaluation of alpha-adrenoceptor agonistic activity of RDS-127 (2-di-n-propylamino-4,7-dimethoxyindane) in rabbit and rat aortae

Arch Int Pharmacodyn Ther. 1991 Mar-Apr:310:76-86.

Abstract

The alpha-adrenergic activity of a dopamine receptor agonist, 2-di-n-propylamino-4,7-dimethoxyindane (RDS-127), has been studied on isolated rabbit and rat aortic strips. In both tissues, RDS-127 produced concentration-dependent contractions and its potency was not significantly different from that of phenylephrine. RDS-127-induced contractions were antagonized competitively by both prazosin and phentolamine in rabbit aortic strips, but the antagonists were noncompetitive in rat aortic strips.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenergic alpha-Agonists / pharmacology*
  • Adrenergic alpha-Antagonists / pharmacology
  • Animals
  • Aorta, Thoracic / drug effects
  • Dopamine Agents / pharmacology*
  • Female
  • In Vitro Techniques
  • Indans / antagonists & inhibitors
  • Indans / pharmacology*
  • Male
  • Muscle Contraction / drug effects
  • Muscle, Smooth, Vascular / drug effects*
  • Phentolamine / pharmacology
  • Phenylephrine / antagonists & inhibitors
  • Phenylephrine / pharmacology
  • Prazosin / pharmacology
  • Rabbits
  • Rats

Substances

  • Adrenergic alpha-Agonists
  • Adrenergic alpha-Antagonists
  • Dopamine Agents
  • Indans
  • Phenylephrine
  • 2-N,N-di-n-propylamino-4,7-dimethoxyindan
  • Prazosin
  • Phentolamine