RLS3: fine-mapping of an autosomal dominant locus in a family with intrafamilial heterogeneity

K M Liebetanz; J Winkelmann; C Trenkwalder; B Pütz; M Dichgans; T Gasser; B Müller-Myhsok

doi:10.1212/01.wnl.0000224886.65213.b5

RLS3: fine-mapping of an autosomal dominant locus in a family with intrafamilial heterogeneity

Neurology. 2006 Jul 25;67(2):320-1. doi: 10.1212/01.wnl.0000224886.65213.b5.

Authors

K M Liebetanz¹, J Winkelmann, C Trenkwalder, B Pütz, M Dichgans, T Gasser, B Müller-Myhsok

Affiliation

¹ Department of Clinical Neurophysiology, Georg-August-University, Goettingen, Germany.

PMID: 16864828
DOI: 10.1212/01.wnl.0000224886.65213.b5

Abstract

A new locus for restless legs syndrome (RLS3) was identified on chromosome 9p24-22. The authors analyzed transmission disequilibrium tests (TDTs) and affecteds-only linkage analysis in one large family of Bavarian origin, taking into account age at onset. P values were 0.0054 for marker D9S1810 for TDT and 0.0009 for the affecteds-only linkage analysis, providing a confirmation of RLS3. This study narrows the region containing the autosomal dominant RLS3 locus to 11.1 cM (16.6 Mbp).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chromosome Disorders / epidemiology*
Chromosome Disorders / genetics*
Chromosome Mapping / methods
Chromosomes, Human, Pair 9 / genetics*
Family
Female
Genes, Dominant
Genetic Predisposition to Disease / epidemiology
Genetic Predisposition to Disease / genetics
Germany / epidemiology
Heterozygote
Humans
Incidence
Male
Middle Aged
Pedigree
Restless Legs Syndrome / epidemiology*
Restless Legs Syndrome / genetics*
Risk Assessment / methods*
Risk Factors