Molecular, functional, and pathological aspects of the mitochondrial ADP/ATP carrier

C Dahout-Gonzalez; H Nury; V Trézéguet; G J-M Lauquin; E Pebay-Peyroula; G Brandolin

doi:10.1152/physiol.00005.2006

Molecular, functional, and pathological aspects of the mitochondrial ADP/ATP carrier

Physiology (Bethesda). 2006 Aug:21:242-9. doi: 10.1152/physiol.00005.2006.

Authors

C Dahout-Gonzalez¹, H Nury, V Trézéguet, G J-M Lauquin, E Pebay-Peyroula, G Brandolin

Affiliation

¹ Département de Réponse et Dynamique Cellulaires, CEA-Grenoble, Laboratoire de Biochimie et Biophysique des Systèmes Intégrés, UMR 5092 CEA-CNRS-Université Joseph Fourier, Grenoble, France.

PMID: 16868313
DOI: 10.1152/physiol.00005.2006

Abstract

In providing the cell with ATP generated by oxidative phosphorylation, the mitochondrial ADP/ATP carrier plays a central role in aerobic eukaryotic cells. Combining biochemical, genetic, and structural approaches contributes to understanding the molecular mechanism of this essential transport system, the dysfunction of which is implicated in neuromuscular diseases.

Publication types

Review

MeSH terms

Animals
Atractyloside / analogs & derivatives
Atractyloside / chemistry
Atractyloside / pharmacology
Cell Respiration / physiology
Gene Expression / drug effects
Gene Expression / physiology
Humans
Mitochondria, Muscle / physiology
Mitochondrial ADP, ATP Translocases / chemistry
Mitochondrial ADP, ATP Translocases / genetics
Mitochondrial ADP, ATP Translocases / physiology*
Neuromuscular Diseases / physiopathology*

Substances

Atractyloside
Mitochondrial ADP, ATP Translocases
carboxyatractyloside