FOXP3 and NFAT: partners in tolerance

Cell. 2006 Jul 28;126(2):253-6. doi: 10.1016/j.cell.2006.07.005.

Abstract

Regulatory T cells suppress autoimmune responses to self-antigens. Recent studies, including one in this issue of Cell (Wu et al., 2006), suggest that the ability of T cells to choose between launching a productive immune response, functional inactivation, or developing into regulatory T cells depends upon the interplay of the key transcriptional regulators FOXP3 and NFAT.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review
  • Comment

MeSH terms

  • Amino Acid Sequence
  • Amino Acid Substitution
  • Autoimmunity
  • Base Sequence
  • Biomarkers / metabolism
  • CD24 Antigen / immunology
  • Crystallography, X-Ray
  • Forkhead Transcription Factors / chemistry
  • Forkhead Transcription Factors / genetics
  • Forkhead Transcription Factors / immunology*
  • Gene Expression Regulation / genetics
  • Gene Expression Regulation / immunology
  • Genes, Reporter
  • Humans
  • Hydrogen Bonding
  • Immune Tolerance*
  • Interleukin-2 / genetics
  • Interleukin-2 / immunology
  • Jurkat Cells
  • Luciferases / metabolism
  • Lymphocyte Activation
  • Models, Biological
  • Molecular Sequence Data
  • NFATC Transcription Factors / chemistry
  • NFATC Transcription Factors / genetics
  • NFATC Transcription Factors / immunology*
  • Protein Structure, Tertiary
  • Receptors, Interleukin-2 / immunology
  • Sequence Homology, Amino Acid
  • T-Lymphocytes, Regulatory / immunology

Substances

  • Biomarkers
  • CD24 Antigen
  • FOXP3 protein, human
  • Forkhead Transcription Factors
  • Interleukin-2
  • NFATC Transcription Factors
  • Receptors, Interleukin-2
  • Luciferases