Boronated thymidine analogues for boron neutron capture therapy

B T S Thirumamagal; Jayaseharan Johnsamuel; Guirec Y Cosquer; Youngjoo Byun; Junhua Yan; Sureshbabu Narayanasamy; Werner Tjarks; Rolf F Barth; Ashraf S Al-Madhoun; Staffan Eriksson

doi:10.1080/15257770600793844

Boronated thymidine analogues for boron neutron capture therapy

Nucleosides Nucleotides Nucleic Acids. 2006;25(8):861-6. doi: 10.1080/15257770600793844.

Authors

B T S Thirumamagal¹, Jayaseharan Johnsamuel, Guirec Y Cosquer, Youngjoo Byun, Junhua Yan, Sureshbabu Narayanasamy, Werner Tjarks, Rolf F Barth, Ashraf S Al-Madhoun, Staffan Eriksson

Affiliation

¹ College of Pharmacy, The Ohio State University, Columbus, Ohio 43120, USA.

PMID: 16901817
DOI: 10.1080/15257770600793844

Abstract

Concise synthetic methods for synthesizing 3-carboranyl thymidine analogues (3CTAs) modified with cyclic and acyclic alcohols have been developed. The synthesis of these potential boron neutron capture therapy (BNCT) agents and their preliminary biological evaluation is described.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Boron Compounds / chemical synthesis
Boron Compounds / chemistry*
Boron Compounds / metabolism
Boron Neutron Capture Therapy*
Humans
Neoplasms / radiotherapy*
Phosphorylation
Thymidine / analogs & derivatives*
Thymidine Kinase / metabolism

Substances

Boron Compounds
Thymidine Kinase
thymidine kinase 1
Thymidine