Abstract
Cell substratum adhesion influences a variety of processes including motility, proliferation and survival. In recent years, it has become clear that there are proteins that are capable of shuttling between cell adhesion zones and the nucleus, providing a mechanism for transcellular coordination and communication. Recent findings have given insight into the physiological signals that trigger trafficking of focal adhesion constituents to the nucleus, where they make diverse contributions to the control of gene expression.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Adaptor Proteins, Signal Transducing
-
Animals
-
Cell Membrane / metabolism*
-
Cell Nucleus / metabolism*
-
Cell-Matrix Junctions / metabolism*
-
Gene Expression Regulation
-
Humans
-
Integrins / metabolism
-
Intracellular Signaling Peptides and Proteins / metabolism
-
Membrane Proteins / metabolism
-
Metalloproteins / metabolism
-
Muscle Proteins / metabolism
-
Nuclear Proteins / genetics
-
Nuclear Proteins / metabolism
-
Paxillin / genetics
-
Paxillin / metabolism
-
Proto-Oncogene Proteins c-abl / metabolism
-
Zyxin
Substances
-
Adaptor Proteins, Signal Transducing
-
ITGB1BP1 protein, human
-
Integrins
-
Intracellular Signaling Peptides and Proteins
-
Membrane Proteins
-
Metalloproteins
-
Muscle Proteins
-
Nuclear Proteins
-
Paxillin
-
Zyx protein, mouse
-
Zyxin
-
Proto-Oncogene Proteins c-abl