Abstract
Central antimuscarinic actions of dopamine receptor agonists: N,N-dipropylaminotetrain (TL-68) and 2-di-n-propylamino-4,7-dimethoxyindane (RDS-127), were evaluated against oxotremorine-induced tremors in mice. Both TL-68 and RDS-127 inhibited the tremor intensity but were less potent than atropine.
MeSH terms
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Animals
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Atropine / therapeutic use
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Dopamine Agents / therapeutic use*
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Indans / therapeutic use*
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Indenes / therapeutic use*
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Male
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Mice
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Naphthalenes / therapeutic use*
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Oxotremorine / toxicity
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Parasympatholytics*
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Tetrahydronaphthalenes / therapeutic use*
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Tremor / chemically induced
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Tremor / drug therapy*
Substances
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Dopamine Agents
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Indans
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Indenes
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Naphthalenes
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Parasympatholytics
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Tetrahydronaphthalenes
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N,N-dipropyl-2-aminotetralin
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Oxotremorine
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Atropine
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2-N,N-di-n-propylamino-4,7-dimethoxyindan