Dopamine receptor agonists, N,N-dipropyl-2-aminotetralin (TL-68) and 2-di-n-propylamino-4,7-dimethoxyindane (RDS-127) antagonize oxotremorine-induced tremors by antimuscarinic action in mice

Arch Int Physiol Biochim. 1990 Mar;98(1):7-9. doi: 10.3109/13813459009115730.

Abstract

Central antimuscarinic actions of dopamine receptor agonists: N,N-dipropylaminotetrain (TL-68) and 2-di-n-propylamino-4,7-dimethoxyindane (RDS-127), were evaluated against oxotremorine-induced tremors in mice. Both TL-68 and RDS-127 inhibited the tremor intensity but were less potent than atropine.

MeSH terms

  • Animals
  • Atropine / therapeutic use
  • Dopamine Agents / therapeutic use*
  • Indans / therapeutic use*
  • Indenes / therapeutic use*
  • Male
  • Mice
  • Naphthalenes / therapeutic use*
  • Oxotremorine / toxicity
  • Parasympatholytics*
  • Tetrahydronaphthalenes / therapeutic use*
  • Tremor / chemically induced
  • Tremor / drug therapy*

Substances

  • Dopamine Agents
  • Indans
  • Indenes
  • Naphthalenes
  • Parasympatholytics
  • Tetrahydronaphthalenes
  • N,N-dipropyl-2-aminotetralin
  • Oxotremorine
  • Atropine
  • 2-N,N-di-n-propylamino-4,7-dimethoxyindan