Nothing in glycobiology makes sense, except in the light of evolution

Ajit Varki

doi:10.1016/j.cell.2006.08.022

Nothing in glycobiology makes sense, except in the light of evolution

Cell. 2006 Sep 8;126(5):841-5. doi: 10.1016/j.cell.2006.08.022.

Author

Ajit Varki¹

Affiliation

¹ Glycobiology Research and Training Center, Departments of Medicine and Cellular & Molecular Medicine, University of California at San Diego, La Jolla, CA 92093, USA. a1varki@ucsd.edu

PMID: 16959563
DOI: 10.1016/j.cell.2006.08.022

Abstract

The remarkable structural diversity of glycans in nature, and their roles in cellular processes, host-pathogen interactions, biological diversity and speciation can be explained by evolutionary processes.

MeSH terms

Animals
Evolution, Molecular*
Gene Expression Regulation, Enzymologic*
Genetic Speciation
Glycoproteins / metabolism*
Glycosylation
Glycosyltransferases / genetics*
Glycosyltransferases / metabolism
Humans
Membrane Glycoproteins / metabolism
Orthomyxoviridae / metabolism
Orthomyxoviridae / pathogenicity
Polysaccharides / metabolism
Protein Processing, Post-Translational*
Protein Transport

Substances

Glycoproteins
Membrane Glycoproteins
Polysaccharides
Glycosyltransferases