Abstract
We analyzed the expression of Fc epsilon R2/CD23 on peripheral blood macrophages/monocytes in 12 patients with Kawasaki disease (KD) using a fluorescence-activated cell sorter. The absolute counts of CD14+ macrophages/monocytes and CD23+ macrophages/monocytes were high, and were positively correlated during the acute stage of KD. These results indicate that the increased number of macrophages/monocytes during acute KD have the Fc epsilon R2/CD23 antigen present on the surface of the cells, suggesting that peripheral blood macrophages/monocytes have been activated.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acute Disease
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Antigens, CD / analysis*
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Antigens, Differentiation, B-Lymphocyte / analysis*
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Antigens, Differentiation, B-Lymphocyte / metabolism*
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Antigens, Differentiation, Myelomonocytic / analysis
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Flow Cytometry
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Humans
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Immunoglobulin E / metabolism
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Lipopolysaccharide Receptors
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Macrophage Activation
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Macrophages / immunology*
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Monocytes / immunology*
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Mucocutaneous Lymph Node Syndrome / immunology*
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Receptors, Fc / analysis*
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Receptors, Fc / metabolism*
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Receptors, IgE
Substances
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Antigens, CD
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Antigens, Differentiation, B-Lymphocyte
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Antigens, Differentiation, Myelomonocytic
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Lipopolysaccharide Receptors
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Receptors, Fc
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Receptors, IgE
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Immunoglobulin E