Abstract
Thirty-seven patients with idiopathic thrombocytopenic purpura (ITP) were treated with a standard Helicobacter pylori eradication regimen irrespective of H. pylori infection. Our results indicate that platelet recovery results from the disappearance of H. pylori itself, and is mediated, in part, through suppression of anti-platelet autoantibody production.
Publication types
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Comparative Study
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Anti-Bacterial Agents / pharmacology
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Anti-Bacterial Agents / therapeutic use
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Antibodies, Bacterial / biosynthesis*
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Antibodies, Bacterial / blood
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Autoantibodies / biosynthesis*
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Autoantibodies / blood
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Blood Platelets / drug effects
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Blood Platelets / immunology*
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Blood Platelets / microbiology
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Female
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Helicobacter Infections / blood*
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Helicobacter Infections / drug therapy
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Helicobacter Infections / microbiology
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Helicobacter pylori / drug effects*
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Helicobacter pylori / immunology*
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Humans
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Male
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Middle Aged
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Platelet Count
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Prospective Studies
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Purpura, Thrombocytopenic, Idiopathic / blood*
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Purpura, Thrombocytopenic, Idiopathic / drug therapy
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Purpura, Thrombocytopenic, Idiopathic / microbiology
Substances
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Anti-Bacterial Agents
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Antibodies, Bacterial
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Autoantibodies