Abstract
The complete amino-acid sequence of the bovine olfactory epithelium adenosine 3',5'-cyclic monophosphate (cAMP)-gated channel has been determined by cloning and sequencing its cDNA. It exhibits a high degree of sequence homology with the cGMP-gated channel of rod photoreceptors, suggesting that cyclic nucleotide-gated channels fall into a new family of genetically related proteins.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Cattle
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Cloning, Molecular
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Cyclic AMP / physiology*
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Cyclic GMP / physiology
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Ion Channel Gating
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Ion Channels / chemistry*
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Ion Channels / genetics*
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Molecular Sequence Data
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Neurons / chemistry*
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Olfactory Mucosa / chemistry*
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Poly A / genetics
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RNA, Messenger / genetics
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Sequence Homology, Nucleic Acid
Substances
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Ion Channels
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RNA, Messenger
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Poly A
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Cyclic AMP
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Cyclic GMP