Nosocomial spread of OXA-58-positive carbapenem-resistant Acinetobacter baumannii isolates in a paediatric hospital in Greece

L Poirel; E Lebessi; C Héritier; A Patsoura; M Foustoukou; P Nordmann

doi:10.1111/j.1469-0691.2006.01537.x

Nosocomial spread of OXA-58-positive carbapenem-resistant Acinetobacter baumannii isolates in a paediatric hospital in Greece

Clin Microbiol Infect. 2006 Nov;12(11):1138-41. doi: 10.1111/j.1469-0691.2006.01537.x.

Authors

L Poirel¹, E Lebessi, C Héritier, A Patsoura, M Foustoukou, P Nordmann

Affiliation

¹ Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, Le Kremlin-Bicêtre, France.

PMID: 17002616
DOI: 10.1111/j.1469-0691.2006.01537.x

Abstract

Twelve non-repetitive Acinetobacter baumannii isolates producing the carbapenem-hydrolysing oxacillinase OXA-58 were recovered from patients in the same paediatric hospital in Athens, Greece, between November 2003 and May 2005. All isolates were clonally related, but the bla(OXA-58) gene was not always plasmid-located and there were variations in the DNA sequences surrounding the OXA-58 gene in different isolates. This study emphasises the importance of the bla(OXA-58) carbapenemase gene in conferring carbapenem resistance among A. baumannii isolates in Greece.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acinetobacter Infections / epidemiology*
Acinetobacter Infections / microbiology
Acinetobacter baumannii / drug effects*
Acinetobacter baumannii / enzymology*
Acinetobacter baumannii / isolation & purification
Carbapenems / pharmacology*
Child
Cross Infection / epidemiology*
Cross Infection / microbiology
Disease Outbreaks*
Drug Resistance / genetics*
Greece / epidemiology
Hospitals, Pediatric
Hospitals, Urban
Humans
Risk Factors
beta-Lactamases / genetics
beta-Lactamases / metabolism*

Substances

Carbapenems
beta-Lactamases