Abstract
A gene has been identified that is expressed specifically in stromal cells surrounding invasive breast carcinomas. On the basis of its sequence, the product of this gene, named stromelysin-3, is a new member of the family of metalloproteinase enzymes which degrade the extracellular matrix. The suggestion is that stromelysin-3 is one of the stroma-derived factors that have long been postulated to play an important part in progression of epithelial malignancies.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Base Sequence
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Breast Neoplasms / enzymology
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Breast Neoplasms / genetics*
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Cloning, Molecular
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DNA / genetics
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Embryo, Mammalian / metabolism
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Extracellular Matrix / enzymology
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Female
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Fibroblasts / metabolism
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Gene Expression
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Growth Substances / pharmacology
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Humans
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Matrix Metalloproteinase 11
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Metalloendopeptidases / genetics*
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Molecular Sequence Data
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Nucleic Acid Hybridization
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RNA / analysis
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Tetradecanoylphorbol Acetate / pharmacology
Substances
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Growth Substances
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RNA
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DNA
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Matrix Metalloproteinase 11
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Metalloendopeptidases
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Tetradecanoylphorbol Acetate