Synthesis and activity of a potent, specific azabicyclo[3.3.0]-octane-based DPP II inhibitor

Bioorg Med Chem Lett. 2007 Jan 15;17(2):507-10. doi: 10.1016/j.bmcl.2006.10.012. Epub 2006 Oct 10.

Abstract

A cell permeable DPP II [also known as DPP2, DPP7, and quiescent cell proline dipeptidase (QPP)] inhibitor has been synthesized. The azabicyclo[3.3.0]octane-based inhibitor is potent and selective and elicits very similar quiescent lymphocyte death to previously characterized inhibitors that are not as selective.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Apoptosis / drug effects
  • Aza Compounds / chemical synthesis*
  • Aza Compounds / pharmacology*
  • Cell Death / drug effects
  • Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / antagonists & inhibitors*
  • Humans
  • In Vitro Techniques
  • Jurkat Cells
  • Kinetics
  • Lymphocytes / drug effects
  • Octanes / chemical synthesis*
  • Octanes / pharmacology*
  • Protease Inhibitors / chemical synthesis*
  • Protease Inhibitors / pharmacology*

Substances

  • Aza Compounds
  • Octanes
  • Protease Inhibitors
  • azabicyclo(3.3.0)-octane
  • Dipeptidyl-Peptidases and Tripeptidyl-Peptidases
  • dipeptidyl peptidase II