Abstract
A cell permeable DPP II [also known as DPP2, DPP7, and quiescent cell proline dipeptidase (QPP)] inhibitor has been synthesized. The azabicyclo[3.3.0]octane-based inhibitor is potent and selective and elicits very similar quiescent lymphocyte death to previously characterized inhibitors that are not as selective.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Apoptosis / drug effects
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Aza Compounds / chemical synthesis*
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Aza Compounds / pharmacology*
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Cell Death / drug effects
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Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / antagonists & inhibitors*
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Humans
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In Vitro Techniques
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Jurkat Cells
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Kinetics
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Lymphocytes / drug effects
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Octanes / chemical synthesis*
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Octanes / pharmacology*
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Protease Inhibitors / chemical synthesis*
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Protease Inhibitors / pharmacology*
Substances
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Aza Compounds
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Octanes
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Protease Inhibitors
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azabicyclo(3.3.0)-octane
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Dipeptidyl-Peptidases and Tripeptidyl-Peptidases
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dipeptidyl peptidase II