Abstract
The selective loss of a particular subset of neurons is a common feature of neurodegenerative disorders. A failure in respiratory chain complex activities in mitochondria seems to be a causative factor. The aim of this review is to describe the most important toxins affecting the mitochondrial function, which could be involved in the incidence of some of these diseases: MPTP, rotenone and 3-nitropropionic (3-NPA).
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Disease Models, Animal
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Humans
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Huntington Disease / chemically induced
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MPTP Poisoning / chemically induced*
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Mitochondria / drug effects*
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Neurodegenerative Diseases / chemically induced*
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Nitro Compounds / toxicity*
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Parkinson Disease, Secondary / chemically induced
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Propionates / toxicity*
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Rotenone / toxicity*
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Succinate Dehydrogenase / antagonists & inhibitors
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Tetrahydroisoquinolines / chemistry
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Tetrahydroisoquinolines / metabolism
Substances
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Nitro Compounds
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Propionates
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Tetrahydroisoquinolines
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Rotenone
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Succinate Dehydrogenase
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3-nitropropionic acid