Base damage and single-strand break repair: mechanisms and functional significance of short- and long-patch repair subpathways

Paola Fortini; Eugenia Dogliotti

doi:10.1016/j.dnarep.2006.10.008

Base damage and single-strand break repair: mechanisms and functional significance of short- and long-patch repair subpathways

DNA Repair (Amst). 2007 Apr 1;6(4):398-409. doi: 10.1016/j.dnarep.2006.10.008. Epub 2006 Nov 28.

Authors

Paola Fortini¹, Eugenia Dogliotti

Affiliation

¹ Department of Environment and Primary Prevention, Section of Molecular Epidemiology, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.

PMID: 17129767
DOI: 10.1016/j.dnarep.2006.10.008

Abstract

A large variety of DNA lesions induced by environmental agents or arising as an outcome of cellular metabolism are counteracted by a complex network of proteins that belong to the base excision repair/single strand break repair (BER/SSBR) processes. No matter whether the initial lesions are modified DNA bases or single-strand breaks with non-conventional termini these processes are completed either by replacement of a single (short-patch, SP) or more (long-patch, LP) nucleotides by different arrays of proteins. Here, the factors that are involved in the selection between SP- and LP-BER/SSBR are reviewed. The biological significance of these alternative subpathways is also presented as inferred from mutant mouse/cell models.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Base Sequence
DNA Breaks, Single-Stranded*
DNA Damage / genetics*
DNA Repair Enzymes / metabolism*
DNA Repair* / genetics
Environment
Mice
Mice, Mutant Strains

Substances

DNA Repair Enzymes