Abstract
Thirty patients with chronic schizophrenia and 30 age-matched controls performed the Attention Network Test (ANT). A subset of the patient group (n=18) also had available magnetic resonance diffusion tensor imaging (DTI) measures of the cingulum bundle (CB) fractional anisotropy and volume. The patients showed a significantly different pattern of ANT performance, characterized primarily by decreased alerting efficiency. In addition, left CB fractional anisotropy correlated significantly with orienting of attention. Smaller right CB volume also correlated with reduced alertness, but not when covarying for medication and illness duration.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Adolescent
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Adult
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Anisotropy
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Arousal / physiology
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Attention / physiology*
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Chronic Disease
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Diffusion Magnetic Resonance Imaging*
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Dominance, Cerebral / physiology
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Gyrus Cinguli / physiopathology*
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Humans
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Image Processing, Computer-Assisted*
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Imaging, Three-Dimensional*
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Male
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Middle Aged
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Nerve Net / physiopathology*
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Neuropsychological Tests
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Orientation / physiology
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Pattern Recognition, Visual / physiology
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Problem Solving / physiology
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Reaction Time / physiology
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Schizophrenia / diagnosis
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Schizophrenia / physiopathology*