2,3,7,8-Tetrachlorodibenzo-P-dioxin as a possible activator of HIV infection

A G Pokrovsky; A I Cherykh; O N Yastrebova; I B Tsyrlov

doi:10.1016/0006-291x(91)91331-6

2,3,7,8-Tetrachlorodibenzo-P-dioxin as a possible activator of HIV infection

Biochem Biophys Res Commun. 1991 Aug 30;179(1):46-51. doi: 10.1016/0006-291x(91)91331-6.

Authors

A G Pokrovsky¹, A I Cherykh, O N Yastrebova, I B Tsyrlov

Affiliation

¹ Department of Virology, Institute of Molecular Biology, Novosibirsk-Koltsovo, USSR.

PMID: 1715696
DOI: 10.1016/0006-291x(91)91331-6

Abstract

The effects of 10-150 nM 2,3,7,8-TCDD on the HIV infection in the various lymphoid cell cultures have been studied. The level of reproduction of HIV was examined by determination of virus antigen as well as by measurement of reverse trascriptase activity. 2,3,7,8-TCDD does not exert any toxic influence in this concentration on the MT-4 cells and causes the induction of cytochrome P-450-containing monooxygenase. Furthermore, in MT-4 cell culture infected by HIV-1 virus an increase of virus production after a treatment of cells with 2,3,7,8-TCDD has been revealed.

MeSH terms

Antigens, Viral / analysis
Cell Line
Dose-Response Relationship, Drug
Enzyme-Linked Immunosorbent Assay
HIV-1 / drug effects
HIV-1 / enzymology
HIV-1 / physiology*
Humans
Kinetics
Lymphocytes
Polychlorinated Dibenzodioxins / pharmacology*
RNA-Directed DNA Polymerase / metabolism
Viral Proteins / analysis
Viral Proteins / biosynthesis
Virus Replication / drug effects

Substances

Antigens, Viral
Polychlorinated Dibenzodioxins
Viral Proteins
RNA-Directed DNA Polymerase