Sertoli-Leydig cell tumours of the ovary and testis: a CGH and FISH study

Virchows Arch. 2007 Mar;450(3):267-71. doi: 10.1007/s00428-006-0344-9. Epub 2007 Jan 18.

Abstract

We present two malignant cases of Sertoli-Leydig cell tumours (SLCT) of the testis and one ovarian SLCT with benign behaviour. The DNA copy number changes affected chromosome 1, 8, 9p, 10, 11, 12, 16, 19, 22 and X. The present study is the first molecular-cytogenetic analysis of Sertoli-Leydig cell tumours of the testis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Chromosome Aberrations*
  • Female
  • Gene Dosage
  • Humans
  • In Situ Hybridization, Fluorescence
  • Karyotyping
  • Male
  • Ovarian Neoplasms / genetics*
  • Ovarian Neoplasms / metabolism
  • Ovarian Neoplasms / pathology
  • Sertoli-Leydig Cell Tumor / genetics*
  • Sertoli-Leydig Cell Tumor / metabolism
  • Sertoli-Leydig Cell Tumor / pathology
  • Testicular Neoplasms / genetics*
  • Testicular Neoplasms / metabolism
  • Testicular Neoplasms / pathology